第十六期开讲人： Alan Ealy
开讲内容：How to make a better bovine embryo
Alan Ealy, PhD, Associate Professor
Postdoctoral Fellow, Reproductive Biology, University of Missouri-Columbia, 1994-1998
Ph.D., Animal Science, University of Florida, 1994
M.S., Animal Science, Michigan State University, 1990
B.S., Dairy Production, Pennsylvania State University, 1987
Dr. Ealy’s laboratory conducts research in reproductive physiology. His group is interested in understanding the molecular and cellular events controlling embryo and placental development and describing how these events dictate ultimate pregnancy outcome and neonatal health. This work targets cattle and sheep but also has relevance to human pregnancy. Major topics in Dr. Ealy’s laboratory include:
1. Embryo-uterine interactions that control events of early pregnancy;
2. Regulation of interferon-tau expression in ruminants;
3. Placental cell development and differentiation;
4. Impact of reproductive technologies on the developmental origin of health and disease.
Representative peer-reviewed articles：
Cerri, R.L., Thompson, I.M., Kim, I.H., Ealy, A.D., Hansen, P.J., Staples, C.R., Li, J.L., Santos, J.E. and Thatcher, W.W. 2012. Effects of lactation and pregnancy on gene expression of endometrium of Holstein cows at day 17 of the estrous cycle or pregnancy. J. Dairy Sci. 95:5657-5675.
Pennington, K.A. and Ealy, A.D. 2012. The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm. Reprod. Biol. Endocrinol. 10:12.
Rizos, d., Scully, S., Kelly, A.K., Ealy, A.D., Moros, R., Duffy, P., Al Naib, A., Forde, N. and Lonergan, P. 2012. Effects of human chorionic gonadotrophin administration on day 5 after oestrus on corpus luteum characteristics, circulating progesterone and conceptus elongation in cattle. Reprod. Fertil. Devel. 24:472-481.
Zhang, K. and Ealy, A.D. 2012. Disruption of fibroblast growth factor receptor signaling in bovine cumulus-oocyte complexes during in vitro maturation reduces subsequent embryonic development. Domest. Anim. Endocrinol. 42:230-238.
Silva, L.A., Klein, C., Ealy, A.D. and Sharp, D.C. 2011. Conceptus-mediated endometrial vascular changes during early pregnancy in mares: an anatomic, histomorphometric, and vascular endothelial growth factor receptor system immunolocalization and gene expression study. Reproduction 142:593-603.
Yang, Q.E., Fields, S.D., Zhang, K., Ozawa, M., Johnson, S.E. and Ealy, A.D. 2011. Fibroblast growth factor 2 promotes primitive endoderm development in bovine blastocyst outgrowths. Biol. Reprod. 85:946-953.