于瑞涛 副研究员

学历:博士研究生

学科:中药学

电话:13897406734

邮箱:yuruitao@nwipb.cas.cn

地址:青海省西宁市城西区新宁路23号

邮编:810008

简历介绍
于瑞涛,博士,副研究员,硕士生导师,青海省自然科学与工程技术学科带头人,青海省 “高端创新人才千人计划”培养拔尖人才、青海省藏药研究重点实验室副主任。2005年毕业于内蒙古科技大学生物科学专业, 2010年6月毕业于中科院西北高原生物研究所获得博士学位,主要研究方向为中药学及药物化学。主要从事青藏高原特色生物资源药效物质基础、作用机制及纳米载体药物相关研究。作为项目负责人主持或完成的项目14项。发表论文76篇,其中SCI收录论文35篇,被引204次。申请专利49件,其中授权41件,第一发明人授权21件;获得青海省科技成果12项,第一完成人3项。2014年度,2018年度在英国圣安德鲁斯大学访问学者。
研究方向
中药学及药物化学
职务
社会任职
获奖及荣誉
2008年刘永龄奖学金
代表论文
1.Nan WU, Yanfang liu, Xinmiao Liang, Lijuan Mei, Yanduo Tao*, Ruitao YU*. Phytochemical and chemotaxonomic study on Saussurea medusa Maxim. (Compositae). Biochemical Systematics and Ecology. 93(2020)104171
2.Yupei Zhang, XiuWang, Sirong Jiang, Weidong Wang, Xiu Wang, Xiaoke Wu, Nan Wu, Yanduo Tao and Ruitao Yu*,CHEMICAL CONSTITUENTS OF Lepidium latifolium。Chemistry of Natural Compound, 2021, 57(4):767-769
3.Ma Z-Hong, Yu R-Tao*, Song J-Ming*, Facile synthesis of Pr-doped In2O3 nanoparticles and their high gas sensing performance for ethanol, Sensors and Actuators: B. Chemical (2020), doi:https://doi.org/10.1016/j.snb.2020.127377.
4.GuangshuoWang , Yingzhe Zeng , Fei Zhou , Xin Chen , Yingying Ma*, Liyun Zheng ,Meixia Li , Yang Sun, Xiaoyan Liu , Huiying Liu , Ruitao Yu*. One-step solvothermal synthesis of porous MnFe2O4 nano?akes and their magnetorheological properties. Journal of Alloys and Compounds 819 (2020) 153044.
5.Fang Wang , Yingying Ma , Huidan Zhang , Junlong Gu, Jiahao Yin , Xiaopeng Jia , Hui Zhang,Yanming Wang, Xiying Fu, Ruitao Yu*, Zehu Wang, Shuai Han, Guangshuo Wang*. Rheological properties and sedimentation stability of magnetorheological fluid based on multi-walled carbon nanotubes/cobalt ferrite nanocomposites. Journal of Molecular Liquids 324 (2021) 115103
6.Ruixue YU, Ruitao YU*,Zhong LIU*. Inhibition of Two Gastric Cancer Cell Lines Induced By Fucoxanthin Involves Downregulation of Mcl-1 and STAT3, Human Cell, 2018, 31:50-63.
7.Mingyue He, Yingzhe Zeng, Fei Zhou, Guofang Kong, Yanqun La, Wen Chen, Yingying Ma, Ruitao Yu*, Zehu Wang, Zongqi Li, Xiaoyan Liu, Liyun Zheng, Guangshuo Wang*,MnFe2O4 nanoparticles anchored on the surface of MgAl-layered double hydroxide nanoplates for stable magnetorheological fluids. Journal of Molecular Liquids. 319 (2020) 114098.
8.Huaixiu Wen, Bowen Tang, Alan J. Stewart, Yanduo Tao, Yun Shao, Yulei Cui, Huilan Yue, Jinjin Pei, Zenggen Liu, Lijuan Mei, Ruitao Yu*, and Lei Jiang*, Erythritol Attenuates Postprandial Blood Glucose by Inhibiting α-Glucosidase, J. Agric. Food Chem,2018, 66(6):1401-1407.
9.Guangshuo Wang ,Jiahong Geng, Xiongwei Qi , Tianxiang Du , Yingzhe Zeng , Ruitao Yu*, Mingwei Yuan, Hesong Peng. , Haibin Li., Chao Chen*. Rheological performances and enhanced sedimentation stability of mesoporous Fe3O4 nanospheres in magnetorheological fluid. Journal of Molecular Liquids 336 (2021) 116389
10.GuangshuoWang,DexingZhao,NannanLi,Yingzhe Zeng, Shuai Han, Yingying Ma, Xufeng Dong, Ruitao Yu*. Facile synthesis of hierarchically structured ?ower-like Fe3O4 microspheres for high-performance magnetorheological ?uids. Journal of Industrial and Engineering Chemistry. 2019, 79: 217-225
11.Zhimin Shi, Yingzhe Zeng, Xin Chen, Fei Zhou, Liyun Zheng, GuangshuoWang, Jie Gao, Yingying Ma, Lianhong Zheng, Bin Fu, Ruitao Yu*.Mesoporous superparamagnetic cobalt ferrite nanoclusters: synthesis, characterization and application in drug delivery. Journal of Magnetism and Magnetic Materials. 2020.
12.Guangshuo Wang*, Fei Zhou, Tianxiang Du, Ziwei Lu, Yingying Ma*, Jingbo Mu, Yanming Wang, Zhixiao Zhang, Hongwei Che, Xiaoliang Zhang, Ruitao Yu* Controlled assembly of MnFe2O4 nanoparticles on MoS2 nanosheets by a facile sonochemical method. Journal of Magnetism and Magnetic Materials. 2019,476,453-458.
13.HuiZhang, JianchaoWang, YingzheZeng, GuangshuoWang, ShuaiHan, ZhitangYang, BaoweiLi , XiaominWang, JieGao, LiyunZheng, XiaoyanLiu, ZhongchaoHuo, RuitaoYu*, Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery.Physics Letters A. 384 (2020) 126600.
14.Ruixue Yu, Lei Jiang, Lijuan Mei, Yanduo Tao, Ruitao Yu*. Anti-inflammatory effects of alcohol extract from Saussurea medusa Maxim against lipopolysaccharides-induced acute lung injury mice. International Journal of Clinical and Experimental Medicine Research (IJCEMR), 2019, 3(4), 112-118.
15.Ruitao Yu, Zhong Liu, Ruixue Yu, Yun Shao, Lijuan Mei, Yanduo Tao*. Distribution of arctigenin in different organs of Saussurea medusa Maxim. from Qinghai-Tibetan plateau. Journal of medicinal plants research,2012,6(3): 361-365
16.Ruitao Yu, Ruixue Yu, Xingwang Zhang, Dynamic Microwave-Assisted Extraction of Arctigenin from Saussurea medusa Maxim., Chromatographia, 2010, 71, 335–339.
17.Ruitao Yu, Zhong Liu, Yanduo Tao, et al. A simple method for isolation and structural identification of arctigenin from Saussurea Medusa Maxim. by preparation chromatography and single crystal X-ray diffraction. Journal of medicinal plants research.2011,5(6): 979-983.
18.S.-L. Huang, R.-T. Yu, J. Gong, Y. Feng, Y.-L.Dai, F. Hu, Y.-H. Hu, Y.-D. Tao*, Y. Leng*. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice, Diabetologia, 2012, 55:1469–1481.
19.Amelie I. S. Sobczak, Kondwani G. H. Katundu, Fladia A. Phoenix,Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz,Claudia A. Blindauer, Samantha J. Pitt, Terry K. Smith, Ramzi A. Ajjan and Alan J. Stewart*, Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes. Chemical Science. 2021. DOI: 10.1039/d0sc06605b
20.AIS Sobczak, O. Kassaar, S. Khazaipoul, R. Yu, R. Ajjan, CA. Blindauer, SJ. Pitt,AJ. Stewart1 Regulation of coagulation by zinc: characterisation of zinc-dependent heparin neutralisation by fibrinogen and histidine-rich-glycoprotein, CARDIOVASCULAR RESEARCH, 2018
21.于瑞涛,罗智敏,陶燕铎等. HPLC-DAD法测定水母雪莲中牛蒡子苷元含量.药物分析杂志.2010,30(2):294-296
22.于瑞雪,梅丽娟,陶燕铎,于瑞涛*. 藏药水母雪莲乙醇提取物抗炎作用研究. 时珍国医国药 .2017,28(3): 558-560
23.于瑞涛;于瑞雪;陶燕铎;梅丽娟;邵赟.水母雪莲花中牛蒡子苷元的分离制备,天然产物研究与开发,2010,22:109-111
24.于瑞涛;张兴旺;梅丽娟;邵赟;陶燕铎.宽叶独行菜石油醚部分非极性馏分GC-MS分析,分析试验室,2010,29(5):398-400
25.张玉佩,王卫东,蒋思绒,梅丽娟,吴楠,杨小兵,于瑞涛*. 宽叶独行菜质量标准研究. 天然产物研究与开发,2020,32:147-152
26.吴小可,张玉佩,王秀,吴楠,王卫东,梅丽娟,陶燕铎,杨小兵,于瑞涛*. HPLC法测定18种菊科植物中总黄酮醇苷的含量,中国野生植物资源. 2020,39(4):40-43.
27.吴小可,张玉佩,王秀,吴楠,王卫东,梅丽娟,陶燕铎,杨小兵,于瑞涛*.紫外分光光度法测定18种菊科植物中总黄酮的含量,天然产物研究与开发,2020,32:61-66
28.于瑞涛;张玉佩;吴楠;王秀;吴小可;梅丽娟;陶燕铎.柱前衍生RP-HPLC法测定青稞和蛹虫草中16种氨基酸含量,天然产物研究与开发,2020,32:73-78
29.王 秀,张玉佩,吴小可,吴 楠,王卫东,梅丽娟,陶燕铎,杨小兵,于瑞涛*. 正交试验法优化康定鼠尾草中迷迭香酸提取工艺. 中国野生植物资源, 2020,39(11):7-10
30.于瑞涛,刘忠,文怀秀,陶燕铎,梅丽娟,邵 赟。水母雪莲中不同器官铅、镉含量分析,光谱实验室,2011,27(3):1209-1211
31.于瑞涛,赵晓辉,陶燕铎.香叶蒿挥发油化学成分研究.天然产物研究与开发. 2007,19:1005-1008
32.于瑞涛, 刘忠, 陶燕铎, et al. 火焰原子吸收光谱法测定青海不同产地唐古特铁线莲中的5种微量元素[J]. 光谱实验室, 2012, 29(6):3330-3332.
33.于瑞雪,张玉佩,吴楠,王秀,梅丽娟,杨小兵,李世华,于瑞涛*。藏药五脉绿绒蒿提取的总生物碱抗炎作用研究,中药新药与临床药理,2021,32(4):461-466
承担项目
先后主持国家及省部级项目14项。
1.青海自然科学基金面上项目“宽叶独行菜药效物质基础及质量标准研究”(2022.01-2024.12),项目负责人,30万元。
2.青海省科技合作项目“藏药唐古特铁线莲物质基础及基因组学研究”2021-HZ-806(2021.01-2023.12)。项目负责人,90万元。
3.国家自然科学基金“水母雪莲中牛蒡子苷元对葡萄糖摄取的影响及其机制探讨”(2012.01-2014.12),项目负责人,23万元。
4.青海省科技合作项目“基于ITC技术的青藏高原特色生物资源天然化合物与HSA蛋白相互作用及药效活性研究”(2017.7-2019.12)。项目负责人,72万元。
5.中国科学院“西部之光”一般项目“水母雪莲中牛蒡子苷元抗糖尿病机制研究”(2012.07-2015.12),项目负责人,30万元。
6.企业项目“基于心脑血管及肝胆类疾病的新药开发”(2017.7-2021.12)。项目负责人,100万元。
7.西宁市科技局重点研发与转化项目“青稞化学成分及营养品质评价研究”(2018.7-2021.12.31),项目负责人,320万元。
8.“青海省高端创新人才千人计划”培养拔尖人才项目(2018.7.1-2021.12.31),项目负责人,20万元。
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