毕宏涛 研究员

学历:理学博士

学科:糖生物化学

电话:+86-971-6143765

邮箱:bihongtao@hotmail.com

地址:青海省西宁市城西区新宁路23号中国科学院西北高原生物研究所

邮编:810008

简历介绍

毕宏涛,男,中共党员,博士,研究员,硕士生导师。现任青海省藏药药理学和安全性评价研究重点实验室副主任、Food Research International杂志编委(SCI,IF 3.520,JCR:Q1)、国际学术期刊出版社Phcog.Net编委、国际期刊Pharmacognosy Review编委。先后入选青海省“昆仑英才. 高端创新创业人才”领军人才、首批青海省“高端创新人才千人计划”、青海省自然科学与工程技术学科带头人、中国科学院青年创新促进会。先后担任中科院青促会生命分会委员(第四届)、兰州分会委员(第三届),中国民族医药学会科研分会常务理事、副秘书长。

研究方向为糖生物化学,主要从事青藏高原特色生物资源糖生物化学研究,包括糖类化合物结构、药理活性及其在生物体内的生理作用。先后主持国家及省部级项目10项;申请国家发明专利38件(美国专利1件、比利时专利1件),其中授权19件;在Carbohydrate Polymers等国际刊物发表SCI论文37篇,被引586次;参编《中药现代化二十年》等著作2部;参与获得2017年度中国民族医药学会科学技术奖一等奖。

研究方向
糖生物化学
职务
社会任职

Food Research International杂志编委(SCI,IF 3.520,JCR:Q1)、国际学术期刊出版社Phcog.Net编委、国际期刊Pharmacognosy Review编委

获奖及荣誉
代表论文

1. Duo Jie, Tingting Gao, Zhongshu Shan, Jiayin Song, Ming Zhang, Olga Kurskaya, Kirill Sharshov, Lixin Wei*, Hongtao Bi*. Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice. International Journal of Biological Macromolecules, 2020, 146: 45–52. (Corresponding author,SCI,IF 5.162,JCR:Q1,POLYMER SCIENCE)

2. Jiayin Song, Daoyong Li, Zhongshu Shan, Olga Kurskaya, Kirill Sharshov, Tingting Gao, Hongtao Bi*. Photocytotoxicity of white light-emitting diode irradiation on human lens epithelium and retinal pigment epithelium via the JNK and p38 MAPK signaling pathways. Journal of Photochemistry & Photobiology, B: Biology, 2020, 213, 112058. (Corresponding author,SCI,IF 4.383,JCR:Q1,BIOPHYSICS)

3. Zhongshu Shan#, Hongtao Bi#, Angxiu Suonan, Yong Gu, Huan Zhou, Kun Xi, Rui Xiong, Hua Chen, Liang Chen*. Tobacco Mosaic Viral Nanoparticle Inhibited Osteoclastogenesis Through Inhibiting mTOR/AKT Signaling. International Journal of Nanomedicine, 2020, 15: 7143–7153. (Co-first author, SCI,IF 5.115,JCR:Q1,PHARMACOLOGY & PHARMACY)

4. Yajun Qiao, Jiubo Zhao, Cen Li, Ming Zhang, Lixin Wei, Xiaoyuan Zhang*, Olga Kurskaya, Hongtao Bi*, Tingting Gao*. Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice. Annals of Translational Medicine, 2020, 8 (15): 942. (Corresponding author,SCI,IF 3.297,JCR:Q2,MEDICINE, RESEARCH & EXPERIMENTAL)

5. Duo Jie, Zhongshu Shan, Zhiliang Ma, Ming Zhang, Tingting Gao*, Hao Wu, Bin Shan, Lixin Wei*, Hongtao Bi*. Ma-Nuo-Xi decoction has an immunostimulating effect in cyclophosphamide-immunosuppressed mice. Annals of Palliative Medicine, 2020, 9(5): 3249-3260. (Corresponding author,SCI,IF 1.681,JCR:Q3,HEALTH CARE SCIENCES & SERVICES)

6. Lujing Geng, Zhenghua Xia, Lu Yuan, Cen Li, Ming Zhang, Yuzhi Du, Lixin Wei*, Hongtao Bi*. Effects of β-HgS on cell viability and intracellular oxidative stress in PC-12 cells. Metallomics, 2020, 12, 1389-1399. (Corresponding author,SCI,IF 3.796,JCR:Q2,BIOCHEMISTRY & MOLECULAR BIOLOGY)

7. Qiaozhu Tan, Ming Zhang, Lujing Geng, Zhenghua Xia, Cen Li, Muhammad Usman, Yuzhi Du, Lixin Wei*, Hongtao Bi*. Hormesis of methylmercury-human serum albumin conjugate on N9 microglia via ERK/MAPKs and STAT3 signaling pathways. Toxicology and Applied Pharmacology, 2019, 362, 59-66. (Corresponding author,SCI,IF 3.616,JCR:Q1,PHARMACOLOGY & PHARMACY)

8. Qiaozhu Tan, Zhitao Liu, Hong Li, Yongjun Liu, Zhenghua Xia, Yuancan Xiao, Muhammad Usman, Yuzhi Du, Hongtao Bi*, Lixin Wei*. Hormesis of mercuric chloride-human serum albumin adduct on N9 microglial cells via the ERK/MAPKs and JAK/STAT3 signaling pathways. Toxicology, 2018, 408: 62-69. (Corresponding author,SCI,IF 3.265,JCR:Q2,PHARMACOLOGY & PHARMACY)

9. Xiaojuan Huang, Jianbin Ma, Lixin Wei, Jiayin Song, Cen Li, Hongxia Yang, Yuzhi Du, Tingting Gao*, Hongtao Bi*. An antioxidant α-glucan from Cladina rangiferina (L.) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage. International Journal of Biological Macromolecules, 2018, 112, 101-109. (Corresponding author,SCI,IF 5.162,JCR:Q1,POLYMER SCIENCE)

10. Ming Zhang, Hongtao Bi*, Cen Li, Yuzhi Du, Lixin Wei*. pH-Dependent Effects of L-Cysteine on Mercury Dissolution of α-HgS and β-HgS. Biological Trace Element Research, 2018, 185(2), 509-512. (Corresponding author, SCI, IF 3.247, JCR: Q3, BIOCHEMISTRY & MOLECULAR BIOLOGY)

承担项目
目前主持科研项目/课题5项,总经费1250万元。
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